UCB gets Japan clearance for two new drugs






BRUSSELS (Reuters) – Belgian pharmaceutical company UCB has secured two regulatory clearances in Japan, further cementing its worldwide shift to a new generation of drugs.


The company said in a statement on Tuesday that the Japanese Ministry of Health, Labour and Welfare had approved UCB’s Neupro patch to treat Parkinson’s disease and moderate-to-severe Restleg Legs Syndrome in adults.






Otsuka Pharmaceutical has the exclusive rights for developing and marketing Neupro in Japan, with UCB responsible in all other regions worldwide. Neupro is available in 35 countries.


In a separate statement on Tuesday, UCB said its drug Cimzia had been approved in Japan for treatment of rheumatoid arthritis in adults.


UCB is jointly developing the drug there with Astellas Pharma Inc, with UCB manufacturing it and Astellas managing distribution and sales. UCB said it would receive an unspecified milestone payment from Astellas.


Cimzia is currently being sold in over 30 countries, including the United States and in Europe.


UCB, a central nervous system and immunology specialist, is placing its hopes on three new drugs – Cimzia, Neupro and epilepsy treatment Vimpat – as previous blockbuster Keppra, also for epilepsy, faces patent expiries.


(Reporting by Philip Blenkinsop; editing by Patrick Graham)


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Suing the Senate to Kill the Filibuster






Senate Majority Leader Harry Reid has it in for the filibuster. “I think the rules have been abused, and we are going to work to change them,” he told reporters soon after the election. The Nevada Democrat is worked up because Republicans have used it to hold up legislation 389 times since 2007. “We will not do away with the filibuster,” Reid said, but “we are going to make it so we can get things done.” He’d change the rules so filibustering senators would have to go back to doing it the old-fashioned way—talking on the Senate floor nonstop, Jimmy Stewart-style—instead of merely declaring a filibuster and going home, which is the way it’s often done now. He’d also make it so senators could only filibuster final votes and not use it to block every procedural step along the way. Even these modest reforms won’t be easy to pass: To change Senate rules Democrats need 67 votes, 12 of them Republican.


A federal lawsuit now in the U.S. District Court in Washington could do Reid one better. It seeks to outlaw the filibuster as unconstitutional. Common Cause, the left-leaning advocacy group, filed the case on behalf of eight plaintiffs, among them three children of undocumented immigrants who say they would have been naturalized under President Obama’s proposed Dream Act if a GOP filibuster hadn’t blocked it. Lawyers for the plaintiffs argue that unlimited debate isn’t a vital Senate tradition that protects the rights of the minority party, but an historical accident that’s led to the equivalent of minority rule.






e5731  pol filibuster52  01  inline202 Suing the Senate to Kill the FilibusterIllustration by Eleanor DavisFilibuster comes from the Spanish “filibustero,” or pirate


Blame it on Aaron Burr. In his famed farewell address to the Senate in 1805, the vice president urged his colleagues to simplify the body’s rules. They did the next year, eliminating among other things a parliamentary motion that required a simple majority to force an end to debate and move to a vote. Burr thought it unnecessary, since it had only been invoked once in four years. Yet without it, there was no longer a way to stop a determined talker from stalling a vote on a bill he opposed. The Senate didn’t set out to create the filibuster; it was an unintended consequence.


In Washington no opportunity goes unexploited, and by the mid-19th century the filibuster had become a weapon. There have been periodic attempts to weaken it. A rule change in 1917 allowed a two-thirds majority to cut off an obstinate senator, and in 1975 the threshold was lowered further to a three-fifths majority, or 60 votes.


According to Emmet Bondurant, lead counsel for the plaintiffs in the federal suit, the Senate’s power to set its own procedures has come into conflict with another constitutional imperative: majority rule. Bondurant notes that the framers of the Constitution created a supermajority requirement in the Senate for six specific circumstances, among them approving a treaty or impeaching a president. From this, the Common Cause suit infers that the Constitution intends the Senate to decide other matters by majority vote.


In the Federalist Papers, James Madison wrote that requiring a supermajority in Congress would reverse “the fundamental principle of free government,” and that a minority might use it to “extort unreasonable indulgences.” It could be used to “embarrass the administration” and “destroy the energy of the government,” wrote Alexander Hamilton. Says Bondurant: “You take those Federalist Papers and publish them today, and people would think you’re talking about the current dysfunctional Senate.”


At a Dec. 10 hearing, lawyers for the Senate asked the judge in the case, Emmett Sullivan, to dismiss the suit, arguing that the plaintiffs can’t plausibly claim to have been injured by a law that wasn’t enacted. The question of the filibuster, they say, is a political one, not for the courts to decide. Judge Sullivan hasn’t indicated when he’ll rule on letting the case proceed.


Common Cause is stretching to make its point, says Michael Gerhardt, the director of the Center for Law and Government at the University of North Carolina School of Law. Gerhardt, a friend of Bondurant, agreed as a favor to look for weaknesses in the suit before it was filed. Gerhardt points to the 1917 and 1975 changes that made it easier to defeat a filibuster. Reid’s current push for further changes, he says, shows the system is capable of correcting itself.


Bondurant doesn’t buy his friend’s argument. The Senate, he says, has been grappling with the implications of the filibuster for the better part of two centuries. Only the courts can extricate it from its own mess. Reid’s proposals are “a great deal of talk,” says Bondurant. “But he doesn’t have the capacity to deliver.”


The bottom line: Although senators defend the filibuster as fundamental to the democratic process, it’s not mentioned in the Constitution.


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U.N. General Assembly voices concern for Myanmar’s Muslims






UNITED NATIONS (Reuters) – The U.N. General Assembly expressed serious concern on Monday over violence between Rohingya Muslims and Buddhists in Myanmar and called upon its government to address reports of human rights abuses by some authorities.


The 193-nation General Assembly approved by consensus a non-binding resolution, which Myanmar said last month contained a “litany of sweeping allegations, accuracies of which have yet to be verified.”






Outbreaks of violence between ethnic Rakhine Buddhists and the Rohingyas have killed dozens and displaced thousands since June. Rights groups also have accused Myanmar security forces of killing, raping and arresting Rohingyas after the riots. Myanmar said it exercised “maximum restraint” to quell the violence.


The unanimously adopted U.N. resolution “expressing particular concern about the situation of the Rohingya minority in Rakhine state, urges the government to take action to bring about an improvement in their situation and to protect all their human rights, including their right to a nationality.”


At least 800,000 Muslim Rohingyas live in Rakhine State along the western coast of Myanmar, also known as Burma. But Buddhist Rakhines and other Burmese view them as illegal immigrants from neighboring Bangladesh who deserve neither rights nor sympathy.


The resolution adopted on Monday is identical to one approved last month by the General Assembly’s Third Committee, which focuses on human rights. After that vote, Myanmar’s mission to the United Nations said that it accepted the resolution but objected to the Rohingyas being referred to as a minority.


“There has been no such ethnic group as Rohingya among the ethnic groups of Myanmar,” a representative of Myanmar said at the time. “Despite this fact, the right to citizenship for any member or community has been and will never be denied if they are in line with the law of the land.”


(Reporting By Louis Charbonneau; Editing by Paul Simao)


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Mundie, one of Gates’ successors, to retire from Microsoft






NEW YORK (Reuters) – Craig Mundie, one of two Microsoft Corp executives who took over Bill Gates‘ role at the company, has relinquished control of Microsoft’s large research organization and is to retire from the company in 2014.


Mundie is taking on a new role as a senior adviser to Chief Executive Steve Ballmer, according to a memo circulated internally earlier this month but only made public on Monday.






Eric Rudder, another Microsoft veteran, is taking on responsibility for Microsoft Research, Trustworthy Computing, and the Technology Policy Group, which were all run by Mundie.


A 20-year Microsoft veteran, Mundie was one of two men hand-picked by co-founder Gates to take over leadership of the technical side of Microsoft when he retired from day-to-day work at the company in 2008.


Mundie took over responsibility for the company’s long-term research activities, while Ray Ozzie became chief software architect. Ozzie left Microsoft in 2010. According to Ballmer’s memo, Mundie will retire from Microsoft in 2014, when he will be 65.


Mundie’s new role was first reported on Monday by the All Things D tech blog.


(Reporting By Bill Rigby; Editing by Steve Orlofsky)


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Pro-gun rights US petition to deport Piers Morgan






LONDON (AP) — Tens of thousands of people have signed a petition calling for British CNN host Piers Morgan to be deported from the U.S. over his gun control views.


Morgan has taken an aggressive stand for tighter U.S. gun laws in the wake of the Newtown, Connecticut, school shooting. Last week, he called a gun advocate appearing on his “Piers Morgan Tonight” show an “unbelievably stupid man.”






Now, gun rights activists are fighting back. A petition created Dec. 21 on the White House e-petition website by a user in Texas accuses Morgan of engaging in a “hostile attack against the U.S. Constitution” by targeting the Second Amendment. It demands he be deported immediately for “exploiting his position as a national network television host to stage attacks against the rights of American citizens.”


The petition has already hit the 25,000 signature threshold to get a White House response. By Monday, it had 31,813 signatures.


Morgan seemed unfazed — and even amused — by the movement.


In a series of Twitter messages, he alternately urged his followers to sign the petition and in response to one article about the petition said “bring it on” as he appeared to track the petition’s progress.


“If I do get deported from America for wanting fewer gun murders, are there any other countries that will have me?” he wrote.


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Markets steady amid Xmas exodus, US budget doubts






LONDON (AP) — Financial markets were largely steady in holiday-thinned trading Monday though concerns remain over the progress of U.S. budget discussions and the future of the economic reform program in Italy.


For weeks, the discussions between the White House and Congress over a budget deal have been the main driver in markets. If a deal isn’t agreed to by the start of 2013, automatic spending cuts and tax increases worth hundreds of billions of dollars will be imposed — which many economists think could push the U.S. economy back into recession.






The prevailing view has been that a deal would be agreed to in time but as the deadline nears there are growing doubts over whether the U.S. will be able to avoid the so-called “fiscal cliff.”


“The reality is given that the U.S. government is now closed for the holiday break the likelihood of anything other than soothing procrastination is highly unlikely much before the Jan. 1 deadline,” said Michael Hewson, senior market analyst at CMC Markets.


Most markets across Europe were only open for half a day and will only re-open again on Thursday. German markets, and others, were closed for Christmas Eve.


Among those that were open, Britain’s FTSE 100 index of leading British shares closed up 0.2 percent at 5,954.18 while the CAC-40 in France was down an equivalent rate at 3,652.61.


Wall Street was poised for falls at the open in what will also be a holiday-shortened trading day — both Dow futures and the broader S&P 500 futures were down 0.3 percent.


Doubts over the progress of discussions prompted a fairly sizeable sell-off last Friday though many analysts still think there will be agreement on some sort of short-term measures.


“Even if this stopgap measure is implemented it may not be enough to prevent unwanted volatility in equity markets going into 2013 as investors try and assess the adverse impact on the U.S. economy,” said Neil MacKinnon, global macro strategist at VTB Capital.


As well as monitoring developments in the U.S. over the coming days, investors will be keeping a close watch on what’s going on in Italy ahead of a general election in February.


Over the weekend, outgoing Prime Minister Mario Monti indicated that he would be willing to return to the role if pro-reform parties back him.


Over the past year or so, Monti and his technocratic government have won plaudits in the markets for their economic reforms and efforts to get a grip on the country’s borrowing. Italy has the second-highest debt burden among the 17 EU countries that use the euro. Only Greece’s is higher.


Earlier in Asia, Hong Kong’s Hang Seng, closed up 0.1 percent at 22,531.51 while South Korea’s Kospi rose less than 0.1 percent to 1,981.82. Japanese markets were closed for the Emperor’s birthday holiday.


Other financial markets were subdued too. In the currency markets, the euro was up 0.2 percent at $ 1.3224 while the benchmark New York oil price was down 16 cents at $ 88.50 a barrel.


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New Zealand level series thanks to Guptill century






EAST LONDON, South Africa (Reuters) – A brilliant, unbeaten century from opener Martin Guptill led New Zealand to an eight-wicket victory off the final ball against South Africa in the second T20 international on Sunday.


Chasing 169 for victory in 19 overs at Buffalo Park, Guptill helped erase the memory of Friday’s embarrassing capitulation to 86 all out in Durban with a stunning batting display as the tourists reached their target for the loss of just two wickets to level the series 1-1.






Requiring 39 from the final four overs and 11 off the last, Guptill was on 97 and needing four for victory when Rory Kleinveldt bowled the final delivery – a low full toss which was eased away through extra cover.


Guptill’s unbeaten 101 was just the third T20 international century by a New Zealander, the first two belonging to captain Brendon McCullum who was almost anonymous with 17 from 15 balls during a second-wicket partnership of 73 with Guptill.


The right-handed opener was similarly dominant during an opening stand of 76 with Rob Nicol (25) as he drove the Proteas attack impeccably straight and displayed the skills – and patience – so obviously missing from the New Zealand batsman in Durban.


Captain Faf du Plessis led from the front once again as South Africa posted a competitive 165-5 in 19 overs after losing the toss and being asked to bat first.


Du Plessis paced his innings to perfection on a tricky pitch to reach 63 from 43 balls with eight fours and a six in a match reduced to 19 overs per side following a 52-minute floodlight failure.


The deciding match takes place in Port Elizabeth on Wednesday.


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Atheist Kids and Bullying: Just an Xbox and a Football Game Away From Redemption






I’ll never forget the year my eight-year-old daughter came home from school saying she got in trouble for going to the bathroom.


“I was afraid,” she said, “that the devil was coming out of the mirror to get me…. I wanted Aya to stay with me until I was done.”






Like any parent, I sat her down and asked her to tell me why she would ever think a mirror could spawn something as terrifying as that.


“Susie told me because I didn’t believe in god, the devil was coming to take my soul.”


MORE: Bullying the Bullies: What to Do to Save the Next Amanda Todd


“Susie” as we’ll call her, was a fellow eight-year-old student at my daughter’s Catholic school. Susie attended church every Sunday with her family—the same church that many of her classmates to this day all go to.


Was my daughter being bullied for being an atheist? I quickly dismissed it. After all, these were only eight-year-old girls, and it wasn’t like we talked about god hating with our morning cereal.


I soon noticed a new pattern of my daughter: She wouldn’t enter a bathroom without a friend or parent and began wetting the bed at night for fear of our extensive collection of bathroom mirrors pulling her into almighty hell at 2 a.m.


Sure enough, the religious eight-year-old was still pressuring my daughter to consider her morality, spirituality and reason for living daily in the school bathroom.


“When the child goes to school, and encounters for the first time other kids who don’t believe the same thing, whether it’s no belief or a different belief system, that can rock a kid’s world.”


I got on the phone and made sure the principal was aware of the bullying, that the child was reported and that my daughter would hopefully make the choice not to play with her anymore. The school thought I was a little crazy. Bullying was getting punched in the stomach in a dark place behind the school, not a little girl being taunted for not believing she was going to have life eternal. This was a new place they were afraid to gain control of. The principal, a former nun, kept a tight lip.


According to the American Society for the Prevention of Cruelty to Children, every day “an estimated 160,000 students in the U.S. refuse to go to school because they dread the physical and verbal aggression of their peers. Many more attend school in a chronic state of anxiety and depression.”


Courtney Campbell, Professor of Religion and Culture at Oregon State University, says he encountered the same case with his own children who were told at a very early age by some of their “friends” that they were “going to hell.” Though there were no physical beatings, the “psychic bullying” may have been worse.


“There is a phenomenon of religious-bullying at an early age, though in my own view/experience with raising my kids, it’s less of an issue than lookism [obese kids], size [‘big’ bullies], or gender, or clothes, or any of a number of things that kids do to manifest power over others,” says Campbell.


He points out that in most conservative/evangelical/fundamentalist Christian traditions, kids are taught at a very early age in their Sunday schools or summer bible camps that there’s only one path to happiness and salvation. That teaching, absorbed at a young age, is on its own rather threatening to the child.


“When the child goes to school, and encounters for the first time other kids who don’t believe the same thing, whether it’s no belief or a different belief system, that can rock a kid’s world,” Campbell adds.


Blame it on fear, maybe a calling out of one’s most sacred and learned family beleifs, but this form of push and shove is only getting more sophisticated.


Rachel Wagner, Associate Professor for the Department of Philosophy and Religion at Ithaca College and author of Godwired: Religion, Ritual and Virtual Reality, says we are overlooking a major player of the religious bullying model—video games.


“If we compare video games to rituals as similar kinds of interactive experiences that are meant to shape how we see ourselves and others in the world, then we can argue something more basic—that video games (like rituals) can teach people habits of encounter—and offer youth deeply problematic models of encounter with difference,” says Wagner, who adds that in her next book, she’ll argue that religion has always had the ability to be “played” like a game, a religious encounter she coins “shooter religion.”


While Wagner admits it’s very important to remember that all world religions also have “deep and abiding practices urging compassion, understanding, tolerance, and social justice,” in today’s media-soaked society, feeling the need to retreat into a simpler world where people can be reduced to camps can be terribly tempting.


Stacy Pershall, author of Loud in the House of Myself: Memoir of a Strange Girl, says that growing up in Prairie Grove, Arkansas, in an athletics-focused, Christian bible belt, she was used to being surrounded by “Jesus talk.”


Pershall, who was bullied for being a “strange girl,” when young, unathletic and atheist to boot, now works and empowers high school and college students as a writing teacher and mental health speaker.


“Although it still makes my heart pound a little to stand in front of a crowd and admit that I don’t believe in god (as I recently did at Catholic University in D.C.), somebody needs to do it. I get to be the adult who says to kids, ‘I’m an atheist, I have morals, I have friends, I’m happy, and I care about how you feel.’ That’s a wonderful, powerful thing. I get to tell bullied kids who might be considering suicide that they’re not alone, and that they have kindred spirits. It’s what the Flying Spaghetti Monster put me on Earth to do.”


Were you ever bullied? Leave what you were bullied about in COMMENTS.


These are solely the author’s opinions and do not represent those of TakePart, LLC or its affiliates.


Related Stories on TakePart:


• 5 Things to Keep in Mind About Bullying


• A Bully’s Paradise: Hidden Halls, Dark Corners and No Supervision


• Mother Bullied to Abort Unborn Twins?



Amy DuFault is a writer and editor whose work has been published in EcoSalon, Huffington Post, Ecouterre, Organic Spa, Coastal Living, Yahoo!, The Frisky and other online and print publications. In addition to being a former co-owner of an eco-boutique, she coaches and connects the sustainable fashion community to feed her soul. She also dreams of singing in an all-girl punk band even though she has stage fright. @amytropolis | TakePart.com


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Nick Cassavetes Sued For Allegedly Stiffing Twin Canadian Pop Duo on $300K Movie Loan






LOS ANGELES (TheWrap.com) – Nick Cassavetes, Canadian twins and incest – besides three phrases that you probably didn’t expect to read in the same sentence today, they’re also elements of a bizarre new lawsuit that hit the California court system this week.


In a lawsuit filed Tuesday in Los Angeles Superior Court, TwinSpin music – home to twin Canadian pop duo Carmen & Camille – claim that “The Notebook” director failed to pay back a $ 300,000 loan to help make the upcoming drama “Yellow.”






The complaint alleges that the writer-director backed out of an agreement to give the duo parts in the movie and to feature a song of theirs in the Sienna Miller-Ray Liotta film.


The film chronicles a woman who’s addicted to pain pills and is fired from her teaching job for engaging in sexual shenanigans on school grounds. Oh, and she also had a love affair with her brother at one point. According to the suit – which also includes TwinSpin manager John Thomas as a plaintiff – TwinSpin and Cassavetes entered into an agreement in September 2010, in which TwinSpin would loan Cassavetes $ 300,000 to start production on the film.


In return, the suit says, Cassavetes agreed to pay the loan back with interest – for a total of $ 345,000 – the next month. Cassavetes also agreed to cast the duo in speaking roles in the film, use a song of theirs on the soundtrack, and to give Thomas a producer’s credit, the complaint claims.


But the money never came, the suit says – and neither did the roles, the song and the credit, without which the loan never would have been given.


“But for these representations, Plaintiffs never would have entered into the Loan Agreement or otherwise granted the Loan,” the lawsuit reads. “Plaintiffs are informed and believe that Cassavetes never had any intention of casting ‘Carmen & Camille’ in the Picture, or featuring a song by ‘Carmen & Camille’ in the Picture, of providing the producer credit to plaintiff Thomas, or of repaying the loan on a timely basis.”


Cassavetes’ agent has not yet responded to misrepresentation request for comment.


Alleging breach of contract, breach of covenant of good faith and fair dealing, fraudulent misrepresentation and negligent misrepresentation, the suit is asking for damages of $ 500,000, the amount that the plaintiffs believe is currently owed to them by Cassavetes, with accruing interest.


(Pamela Chelin contributed to this report)


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Meanwhile, Deep Inside Your Belly Button …






Dec 23, 2012 7:00am



5846e  gty belly button jt 121222 wblog Meanwhile, Deep Inside Your Belly Button …

Getty Images







Reported by Dr. Amish Patel:


Researchers have found that more than 2,000 different species of bacteria live in our umbilicus – the medical word for belly button.  That means you have more kinds of bacteria in your belly button than there are different kinds of ants or birds in North America, according to the study.


The majority of these bacteria were rare and occurred in just one individual.  No single type was common to all 60 belly buttons sampled.


“I don’t find it alarming,” said Dr. William Schaffner, an expert in infectious diseases at Vanderbilt University Medical Center in Nashville, Tenn.  “We knew belly buttons weren’t sterile.”


However, Schaffner believes that this does not minimize the study’s findings.


“This is in the context of a much larger study, which is trying to … get greater insight into the source of pathogens and how the [bacteria on our body] changes with antimicrobial therapy and age.”


Perhaps, he said, we can “use this to develop new antimicrobials.”


The benefits may extend beyond antibiotics.


“Understanding the biodiversity of our bodies and how it differs among people may play an important role in understanding why some … people are susceptible to the same pathogen or respond to the same drug or diet,” said Dr. Rob Knight, associate professor of molecular biophysics at the University of Colorado – Boulder.


Although the findings of the study do not have any immediate implications, this is good timing for a public service announcement from Dr. Gregory Poland, infectious disease expert at the Mayo Clinic in Rochester, Minn.


“The current fad of women piercing their umbilicus has led to many case reports of infections,” Poland said. “And with today’s multiple drug-resistant bacteria, it can lead to disasters.”



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